Combining many multiple alignments in one improved alignment

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Combining many multiple alignments in one improved alignment

MOTIVATION The fact that the multiple sequence alignment problem is of high complexity has led to many different heuristic algorithms attempting to find a solution in what would be considered a reasonable amount of computation time and space. Very few of these heuristics produce results that are guaranteed always to lie within a certain distance of an optimal solution (given a measure of qualit...

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MOTIVATION Multiple sequence alignment is a fundamental task in bioinformatics. Current tools typically form an initial alignment by merging subalignments, and then polish this alignment by repeated splitting and merging of subalignments to obtain an improved final alignment. In general this form-and-polish strategy consists of several stages, and a profusion of methods have been tried at every...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 1999

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/15.2.122